FLR is convenient when the connection is clean
Florence Airport, also called Peretola or Amerigo Vespucci, sits northwest of the city center. It is a compact airport built around short-haul connections, so a trip from the United States reaches FLR by changing planes at a hub such as Paris, Amsterdam, or Frankfurt.
The useful part comes after landing. The Vespucci tram stops a short walk from the terminal and runs into town past Santa Maria Novella. If the station is your destination, get off at Alamanni beside the station rather than staying aboard to the end.
FLR also has a weather caveat. Strong wind or low cloud can divert an arrival to Pisa or Bologna, with passengers brought back by road. That is exactly the kind of disruption I want an airline to own.
If FLR gives you a sensible connection, keep the trip on the same booking and take the tram into town. I would not add another self-transfer just to force the itinerary onto Florence’s own airport.
Pisa is not a trick if the railway works for you
Pisa International Airport, Galileo Galilei, is Tuscany’s bigger airport and carries more low-cost and leisure traffic than Florence. That makes PSA worth checking before paying for an awkward itinerary into FLR.
The ground side is straightforward. PisaMover runs from outside the terminal to Pisa Centrale, and regional trains continue from there to Firenze Santa Maria Novella. Trenitalia can sell the airport-to-Florence journey as a through ticket with PisaMover included.

If you use a paper regional ticket, validate it before boarding. Italy has enough art without turning a small rectangle of card into an interpretive exercise with an inspector.
I would compare PSA whenever the FLR itinerary adds an ugly connection. The useful comparison is not airport against airport; it is baggage claim at Pisa plus rail against whatever extra airport stop Florence requires.
Pisa also gives you a useful booking test. If the flight is cleaner and the rail connection stays on a normal station-to-station path, the fact that the airport name says Pisa rather than Florence matters surprisingly little once the train reaches Santa Maria Novella.
Bologna and Rome can turn the airport problem into a rail problem
Bologna Guglielmo Marconi Airport gives you another workable chain. Marconi Express links BLQ with Bologna Centrale, where high-speed trains run through the Apennines to Florence.
Rome Fiumicino is farther away but matters because it is Italy’s main intercontinental gateway. The straightforward route is the Leonardo Express from FCO to Roma Termini, then a Frecciarossa to Firenze Santa Maria Novella.
This is where I stop treating an extra airport connection as automatically superior to a train. A long-haul arrival followed by rail can be easier to reason about than a chain of separate flights, especially when the station at the far end drops you into central Florence itself.

Compare the whole chain before paying. If Bologna or Rome gives you a cleaner arrival and a simple train connection, the “wrong” airport may be the more useful booking.
I would especially look at the rail leg when the flight search starts adding awkward airport changes. A station transfer is still a transfer, but at least it ends in central Florence rather than handing you another boarding pass.
The Schengen border may happen before Florence
US passport holders can make short visa-free visits to Italy within the Schengen stay rules. The border check happens where you enter Schengen, not necessarily where the trip ends.
The Entry/Exit System is now fully running. Non-EU travelers have fingerprints and a facial image recorded at the external border, while digital records replace the old passport-stamp routine. There is nothing to apply for before the trip.
That matters when you change planes at a Schengen hub on the way. The border formalities happen there, before the connecting flight to Florence.
ETIAS is different. The authorization is not operating yet, and the official EU site is not collecting applications. Any site selling you an ETIAS today is selling something the real system is not accepting.
I would leave room in a Schengen connection for the border check and ignore ETIAS sellers until travel-europe.europa.eu says applications are live.
Do not collect a rental car just to park it in Florence
Florence’s historic center is a zona a traffico limitato (ZTL), a limited traffic zone. Cameras at the entry gates read license plates, and driving through while the zone is active can trigger a traffic penalty. A rental company can pass that penalty back to the driver and add an admin charge.
This is a bad place for the “I’ll just follow the navigation app” school of trip planning. The camera does not care that the hotel looked accessible on a map.
I would skip the car for Florence itself. If Tuscany beyond the city is part of the trip, collect the rental when you are leaving Florence rather than paying to store it while walking and using city transport.
Spring and autumn make the airport choice easier to enjoy
Spring and autumn are the comfortable walking seasons in Florence. July and August are hot, while winter is cooler and quieter.
That does not change which airport works, but it changes how much friction you will tolerate after landing. A rail transfer that feels perfectly reasonable in mild weather is less charming when the day is hot and you packed as if luggage had no mass.
I would start with spring or autumn if the calendar is flexible, then compare FLR against PSA, BLQ, and FCO by the route to Santa Maria Novella. The cheap ticket wins when the transfer still looks sensible after you stop staring at the flight search.